A Second Receptor Binding Site on Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Contributes to Activation of the Fusion Mechanism Jan. 17, 2007 The hemagglutinin-neuraminidase (HN) protein of paramyxoviruses carries out three discrete activities that affect the ability of HN to promote viral fusion and entry: receptor binding, receptor cleaving, and triggering of the fusion protein. The authors suggest that the two receptor binding sites on HPIV3 HN each contribute in distinct ways to virus-cell interaction; one is the multifunctional site that contains both binding and neuraminidase activities, and the other contains binding activity and also is involved in fusion promotion.
Niche-to-niche migration of bone-marrow-derived cells Jan. 2, 2007 A summary of the current understanding of haematopoietic stem cell (HSC) niche characteristics, and the physiological and pathological mechanisms that guide HSC homing both within the bone marrow and to distant niches in the periphery, promoting new vessel growth in tumors and ischaemia.
Preparing the "Soil": The Premetastatic Niche Dec. 1, 2006 Focus on the early cellular and molecular events in cancer dissemination and selectivity will likely lead to new approaches to detect and prevent metastasis at its earliest inception.
Capsule Endoscopy Called Safe, Clinically Useful Dec. 1, 2006 Dr. Robbyn Sockolow, Division Chief of Gastroenterology in the Department of Pediatrics at Weill Cornell, and her team conduct a study concluding that capsule endoscopy appears safe and effective for the diagnosis and management of children with gastrointestinal diseases.
AMG 531, a Thrombopoiesis-Stimulating Protein for Chronic ITP Oct. 19, 2006 AMG 531, a thrombopoiesis-stimulating protein, caused no major adverse events and increased platelet counts in patients with chronic immune thrombocytopenic purpura (ITP).