Pediatric Nephrology (Kidney Disease)
Infants and children with complex kidney diseases and urologic conditions may find a full range of treatment options through the Komansky Center for Children's Health at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Center provides care and management for various kidney conditions, including:
- Hematuria (blood in the urine)
- Proteinuria (protein in the urine)
- Congenital Kidney Anomalies
- Nephrotic Syndrome
- Acute Glomerulonephritis
- Acute Kidney Failure
- Chronic Kidney Disease
- Hypertension (high blood pressure)
- Kidney Stone Disease
- Electrolyte Disorders
- Urinary Tract Infections
- Vesicoureteral Reflux
- Enuresis (bed wetting) and other Wetting Disorders
Kidney biopsies are routinely performed in children of all ages for diagnostic purposes. Biopsies are performed with ultrasound guidance and conscious sedation.
Twenty-four hour ambulatory blood pressure monitoring is available to evaluate children and adolescents with elevated blood pressure readings. It is an invaluable tool in distinguishing those children with so-called "white coat" hypertension form those with an elevation of their blood pressure load.
For children with end-stage kidney disease, we offer:
- Peritoneal Dialysis
- Kidney Transplantation
Kidney Transplantation Program
The Division, as part of the Rogosin Kidney transplant Center, coordinates and provides care and follow-up of children who require kidney transplantation. The kidney transplantation program offers pre- and post-transplant counseling for patients and family members. There is a very active Living Donor Program offering pre-emptive kidney transplantation. Leading edge therapies are used to help reduce the side effects of anti-rejection drugs. The Division routinely uses a steroid free protocol.
Growth Failure Program
Our staff also has special expertise in the management of children with growth failure resulting from chronic kidney disease. We are particularly interested in why some children with kidney failure do not grow and how recombinant human growth hormone allows them to grow more normally. We are examining the role of cytokines and Leptin in the growth process and their correlation with body composition and growth parameters.
Human immunoglobulin G (IgG) has been shown to have important immunoregulartory roles in addition to its primary role in the humoral immune defense system. Autoantibodies of the IgG class have also been shown to contribute significantly to the pathophysiology of several human autoimmune syndromes.
Unique segments (idiotypes) of immunoglobulin antigen binding sites have been shown to induce autologous autoantibodies – called anti-idiotypic antibodies – both spontaneously and by puposeful induction in a number of circumstances. Normal human serum IgG contains many anti-idiotypic antibodies. The biologic significance of such anti-idiotypic antibodies in health and disease is not clear, but they are believed to contribute to the regulation of immune responses including down-regulation of the primary (idiotype) antibody response.
The potential efficacy of immune globulin intravenous (IGIV) therapy has been studied in many other disease states with an immune or autoimmune inflammatory component with variable results. We have treated two patients with MPGN with intermediate dose IGIV with suggested positive clinical effects. We are continuing our investigation into the effectiveness of this treatment of MPGN in children.
Division of Pediatric Nephrology
505 East 70th Street
Helmsley Tower, 3rd Floor
New York, NY 10021
Phone: (646) 962-4324
Fax: (646) 962-0246
Visit our Kidney Disease patient web page