Research
Members of the Division of Newborn Medicine have been involved in clinical and basic research related to several important groups of neonatal problems:- neonatal respiratory physiology
- mediators of neonatal inflammation and infections
- neonatal growth and development
- neonatal neurologic disorders
- neonatal resuscitation
Dr. Jeffrey Perlman has focused his work on understanding the pathogenesis of common neurologic disorders including periventricular-intraventricular hemorrhage in the premature infant, periventricular white matter injury, hypoxic ischemic brain injury in the term infant, neonatal stroke, neonatal seizures and the genesis of cognitive injury in the preterm infant. He is also involved in many issues related to neonatal resuscitation.
Dr. Alfred N. Krauss has been studying pulmonary and cardiac physiology. He is especially interested in inflammatory cellular markers of bronchopulmonary dysplasia and benefits of different regimens of steroid hormones for treatment of and therapy of persistent pulmonary hypertension with nitric oxide.
Dr. Gail S. Ross has been studying the developmental outcome of different groups of NICU "graduates" for many years and provided valuable information how changes in neonatal clinical practice has influenced the outcome.
Dr. Susan J. Vannucci directs the laboratory of Newborn Medicine, where the research is focused on acute injury to the developing brain, predominantly hypoxia-ischemia, hypoglycemia, and seizures. The overall goal of the research is to delineate the ways in which the neonatal brain is unique in the way it responds to an acute injury, relative to the adult, as well as how it develops following the injury. The laboratory utilizes experimental models in immature rodents to study the pathophysiology of injury as well as the efficacy of therapeutic interventions.
We have developed close collaborations with the faculty members from other divisions and affiliated institutions including:
Dr. Susanna Cunningham-Rundles from the Pediatric Immunology Laboratory
Dr. Barry Kosofsky from Pediatric Neurology
Dr. Shahin Rafii from Hematology/Oncology
